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cisplatin + celecoxib + alpha-type-1 polarized dendritic cell vaccine
- Development stage
- Unknown
- Lead developer
- Roswell Park Comprehensive Cancer Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Small Molecules, Vaccines & Immunotherapeutics
- Administration
- Intraperitoneal, Oral, Intranodal, Intradermal
01
Overview
Cisplatin + celecoxib + DC vaccine is an investigational chemo-immunotherapy combination developed by Roswell Park Comprehensive Cancer Center for the treatment of advanced-stage ovarian cancer. The regimen consists of intraperitoneal cisplatin, a platinum-based DNA alkylating agent; oral celecoxib, a selective COX-2 inhibitor intended to modulate the tumor immune microenvironment; and an autologous alpha-type-1 polarized dendritic cell (alpha-DC1) vaccine. The vaccine is produced from patient-derived monocytes, pulsed with tumor lysate and keyhole limpet hemocyanin (KLH), and matured to induce a tumor-specific T-cell response. This combination is typically evaluated in a neoadjuvant setting alongside intravenous paclitaxel and may be further combined with chemokine modulatory agents like rintatolimod and interferon-alpha to enhance immune cell infiltration into the tumor.
- Other names
- cisplatin + celecoxib + DC vaccinealpha-DC1 vaccine + cisplatin + celecoxib
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DNAHLA-A2-presented tumor blood vessel antigen peptide-MHC complexes
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