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cisplatin + dalotuzumab + pemetrexed
- Development stage
- Discontinued
- Lead developer
- Merck
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
The combination of cisplatin, dalotuzumab, and pemetrexed is an investigational treatment regimen primarily studied for non-small cell lung cancer (NSCLC), particularly non-squamous NSCLC. This combination brings together three distinct agents with complementary mechanisms of action. Dalotuzumab (MK-0646) is a humanized IgG1 monoclonal antibody targeting the Insulin-like Growth Factor 1 Receptor (IGF-1R), aiming to block proliferation and survival signals. Pemetrexed is an antifolate antineoplastic agent disrupting folate-dependent metabolic processes, approved for NSCLC and malignant pleural mesothelioma. Cisplatin is a platinum-based chemotherapy commonly used with pemetrexed in NSCLC. A randomized phase II trial investigating this combination as first-line therapy for non-squamous lung cancer was initiated but closed prematurely due to a sponsoring company's decision and dalotuzumab's overall failure to demonstrate sufficient efficacy in clinical development.
- Brand names
- AlimtaPemfexyAxtle
- Other names
- pemetrexedcisplatindalotuzumab
02
Targets
TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)DNAGART (GAR transformylase)IGF-1R (Insulin-like growth factor 1 receptor)
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