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cisplatin + epirubicin + paclitaxel
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
The combination of cisplatin, epirubicin, and paclitaxel is a multi-agent chemotherapy regimen used primarily in the treatment of advanced epithelial ovarian carcinoma and advanced breast cancer. Cisplatin is a platinum-based chemotherapeutic that forms DNA crosslinks, leading to apoptosis. Epirubicin is an anthracycline that intercalates into DNA and inhibits topoisomerase II, resulting in DNA damage and cell death. Paclitaxel stabilizes microtubules, preventing their depolymerization during cell division, which leads to mitotic arrest and apoptosis. This combination has demonstrated significant antitumor activity with manageable toxicity profiles in clinical studies[1][2][3].
- Other names
- IPEC-GC regimen
02
Targets
TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))DNA
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