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cisplatin + fluorouracil + radiotherapy (Sun Yat-sen University)
- Development stage
- Unknown
- Lead developer
- Sun Yat-sen University
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
This therapeutic regimen is designed for the treatment of advanced nasopharyngeal carcinoma (NPC), specifically targeting patients with N2-3 stage disease. The protocol consists of concurrent chemoradiotherapy (CCRT) followed by adjuvant chemotherapy. During the CCRT phase, patients receive concurrent cisplatin (a platinum-based DNA cross-linking agent) alongside intensity-modulated radiotherapy (IMRT). This is followed by an adjuvant chemotherapy phase known as the PF regimen, which combines cisplatin with 5-fluorouracil (5-FU). 5-fluorouracil is a pyrimidine analog antimetabolite that inhibits thymidylate synthase, thereby interfering with DNA synthesis. This specific treatment sequence was evaluated in a Phase 3 clinical trial conducted by Sun Yat-sen University to compare its efficacy and safety against a gemcitabine plus cisplatin (GP) adjuvant regimen.
- Other names
- CCRT + PF-Sun Yat-sen University-nasopharyngeal carcinomacisplatin/5-FU adjuvant therapy after CCRTPF regimenconcurrent chemoradiotherapy followed by adjuvant cisplatin and 5-fluorouracil
02
Targets
TS (Thymidylate synthase)
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