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cisplatin + ifosfamide + vinblastine

Development stage: Unknown
Lead developer: Michigan State University
Modality: Small Molecules
Administration: Intravenous

Overview

A chemotherapy combination regimen consisting of cisplatin, ifosfamide, and vinblastine. This combination is primarily used as salvage therapy for patients with recurrent germ cell tumors who have failed first-line treatment with cisplatin-etoposide-based regimens. It has also shown effectiveness in treating bulky seminoma. The typical dosing schedule involves vinblastine (0.11 mg/kg/d on days 1 and 2), ifosfamide (1.2-1.5 g/m²/d on days 1 through 5), and cisplatin (20 mg/m²/d on days 1 through 5), with courses repeated every 21 days. The main toxicity associated with this regimen is myelosuppression.

Targets

TUBB (Tubulin (alpha and beta subunits))DNA

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