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cisplatin + nivolumab + pemetrexed
- Development stage
- Unknown
- Lead developer
- Ono Pharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of cisplatin (a platinum-based chemotherapeutic agent), nivolumab (a PD-1 immune checkpoint inhibitor), and pemetrexed (a folate analog metabolic inhibitor). This regimen combines cytotoxic chemotherapy with immunotherapy to treat various cancers, particularly non-small cell lung cancer and malignant pleural mesothelioma. The treatment is typically administered intravenously in 21-day cycles.
- Brand names
- Opdivo (nivolumab)Alimta (pemetrexed)none for cisplatin (generic)
- Other names
- nivolumab, pemetrexed and cisplatin combination
02
Targets
GART (GAR transformylase)DHFR (Dihydrofolate reductase)DNATS (Thymidylate synthase)PDCD1 (Programmed cell death protein 1 receptor)
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