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cisplatin + vinorelbine
- Development stage
- Unknown
- Lead developer
- Pierre Fabre
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Cisplatin + vinorelbine is a combination chemotherapy regimen primarily used for the treatment of non-small cell lung cancer (NSCLC). Cisplatin is a platinum-based chemotherapeutic agent that works by forming DNA crosslinks, thereby inhibiting DNA, RNA, and protein synthesis essential for cancer cell division. Vinorelbine is a semi-synthetic vinca alkaloid that acts as a mitotic spindle poison by binding to tubulin and disrupting microtubule formation during mitosis, leading to cell cycle arrest at the G2/M phase and promoting apoptosis in malignant cells. This combination aims to destroy or slow down the growth of cancer cells and may help control symptoms associated with NSCLC[1][2][3][5][6][8].
- Brand names
- Navelbine
- Other names
- cisplatin + vinorelbineLUAVNP
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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