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citalopram + clopidogrel
- Development stage
- Phase 1
- Lead developer
- Lundbeck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of two pharmaceutical drugs: citalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, and clopidogrel, an antiplatelet agent. Citalopram increases serotonin levels in the brain by inhibiting its reuptake into presynaptic cells, primarily used for treating depression and anxiety disorders. Clopidogrel is a P2Y12 adenosine diphosphate (ADP) receptor antagonist that inhibits platelet aggregation to reduce the risk of cardiovascular events such as heart attack and stroke. The combination may be prescribed in patients with coexisting depression and cardiovascular disease but requires careful monitoring due to increased bleeding risk[2][4][5][9].
- Brand names
- Celexa + Plavix
- Other names
- citalopram + PlavixCelexa + clopidogrel
02
Targets
P2Y12 (Purinergic P2Y12 receptor)SERT (Sodium-dependent serotonin transporter)
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