citalopram + donepezil

Citalopram + donepezil is a combination of two approved small molecule drugs, each with distinct mechanisms of action. Citalopram is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat depression by increasing serotonin levels in the brain through inhibition of its reuptake. Donepezil is an acetylcholinesterase inhibitor indicated for the symptomatic treatment of Alzheimer's disease and other dementias; it works by inhibiting the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. This combination may be considered in patients with comorbid depression and dementia but carries risks due to overlapping side effects, particularly QT interval prolongation[3][4][5][6].