citalopram + escitalopram

This is a combination of two selective serotonin reuptake inhibitors (SSRIs): citalopram and escitalopram. Citalopram is a racemic mixture containing both R- and S-enantiomers, while escitalopram consists solely of the S-enantiomer, which is considered the pharmacologically active component. Both drugs function by inhibiting the reuptake of serotonin in the brain, thereby increasing its availability and enhancing serotonergic neurotransmission. They are primarily indicated for major depressive disorder and generalized anxiety disorder, with additional off-label uses including panic disorder, obsessive-compulsive disorder (OCD), and social anxiety disorder[3][4][5][6][7]. The combination of these two agents in a single formulation or regimen is not standard clinical practice due to their overlapping mechanisms; typically only one would be prescribed at a time.