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Drug intelligence / Profile preview
clenbuterol + nadolol
- Development stage
- Phase 2
- Lead developer
- CuraSen Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
CST-103 + CST-107 (also known as CuraCN or clenbuterol + nadolol) is an oral combination therapy developed by CuraSen Therapeutics for the treatment of neurodegenerative and psychiatric disorders, including Parkinson's disease, mild cognitive impairment (MCI), dementia with Lewy bodies, and major depressive disorder. The combination consists of CST-103 (clenbuterol), a brain-permeant beta-2 adrenergic receptor (β2-AR) agonist, and CST-107 (nadolol), a brain-sparing (peripherally restricted) beta-adrenergic receptor blocker. By co-administering nadolol, the peripheral cardiometabolic side effects of clenbuterol (such as tachycardia, palpitations, and tremors) are minimized, while clenbuterol's central nervous system effects—such as restoring adrenergic stimulus to the brain to compensate for locus coeruleus degeneration—are preserved. The therapy has demonstrated cognitive and mood benefits in Phase 2 clinical trials.
- Other names
- clenbuterol and nadololclenbuterol/nadolol
02
Targets
ADRB1 (β1)ADRB2 (β2)
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