clindamycin + benzoyl peroxide

Clindamycin + benzoyl peroxide is a fixed-dose topical combination used primarily for the treatment of acne vulgaris in patients aged 12 years and older. It combines two active ingredients with complementary mechanisms: - **Clindamycin** is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, thereby preventing *Cutibacterium acnes* (formerly *Propionibacterium acnes*) from growing and replicating. - **Benzoyl peroxide** is an antiseptic and keratolytic agent that kills *C. acnes* by releasing free radical oxygen species to oxidize bacterial proteins. It also helps reduce sebum production and prevents clogged pores. This dual mechanism targets both the microbial cause of acne and associated inflammation while reducing resistance risk due to their different modes of action[1][2][3][4][5].

Brand names

BenzaclinAcanyaNeuac

Other names

clindamycin/benzoyl peroxidebenzoyl peroxide/clindamycin