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clindamycin + primaquine
- Development stage
- Phase 4
- Lead developer
- McGill University Health Centre
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Clindamycin plus primaquine is a combination small molecule therapy utilized as a second-line treatment for Pneumocystis jirovecii pneumonia (PCP), particularly in patients who are intolerant to or fail standard trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Clindamycin is a lincosamide antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of the pathogen. Primaquine is an 8-aminoquinoline antimalarial whose mechanism in PCP is thought to involve the disruption of mitochondrial function and DNA synthesis. The McGill University Health Centre is evaluating this combination in the SPIRIT-ALT phase 4 trial to establish its comparative efficacy and safety against other alternative regimens like pentamidine and atovaquone in immunocompromised populations.
- Other names
- clindamycin plus primaquine
02
Targets
PTC (50S ribosomal peptidyl transferase center)Plasmodium falciparum apicoplast 50S ribosomal subunitDNA
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