Drug intelligence / Profile preview

clindamycin + tetracycline

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

This drug is a combination of two antibiotics, clindamycin and tetracycline, used together primarily for their antibacterial effects. Clindamycin is a lincosamide antibiotic effective against susceptible anaerobic bacteria and gram-positive cocci; it works by inhibiting bacterial protein synthesis. Tetracycline is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. The combination may be used in infections where both drugs' spectra are beneficial or in conditions like hidradenitis suppurativa, where antibiotic combinations are employed for their antibacterial and anti-inflammatory properties. Clindamycin also suppresses bacterial toxin production and leukocyte chemotaxis, reducing inflammation. Tetracycline requires administration considerations such as avoiding concurrent intake with iron-containing products to prevent absorption interference.

Other names
clindamycin + tetracycline
02

Targets

Bacterial RibosomeBacterial 50S ribosomal subunit

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