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clindamycin + tretinoin (Laboratorios Q Pharma)
- Development stage
- Unknown
- Lead developer
- Laboratorios Q Pharma
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
**Metclan** is a topical fixed-dose combination of the lincosamide antibiotic clindamycin and the retinoid tretinoin, developed and manufactured by Laboratorios Q Pharma. The company pipeline identifies the product as containing clindamycin 5 mg plus tretinoin 0.15 mg. Clindamycin inhibits bacterial protein synthesis through binding to the bacterial 50S ribosomal subunit, while tretinoin activates retinoic acid receptors to normalize follicular epithelial differentiation and reduce comedone formation. The product is intended for dermatologic use, with acne vulgaris inferred as the relevant indication based on the established use of topical clindamycin-tretinoin combinations. Comparable clindamycin phosphate and tretinoin topical combination products are indicated for acne vulgaris. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1f772408-52a3-45b2-b053-8fc78948983c))
- Brand names
- Metclan
- Other names
- clindamycin + tretinoin
02
Targets
Bacterial 50S ribosomal subunitRAR (Retinoic acid receptor)
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