Drug intelligence / Profile preview

clioquinol + fluocinolone acetonide

Development stage
Unknown
Lead developer
Offenbach Farmacéutica Mexicana
Modality
Small Molecules
Administration
Topical
01

Overview

Cortilona compuesto is a topical combination dermatological cream containing fluocinolone acetonide, a synthetic corticosteroid, and clioquinol, a halogenated hydroxyquinoline with broad-spectrum antimicrobial properties. Fluocinolone acetonide acts as a potent glucocorticoid receptor agonist to alleviate inflammation, pruritus, and vasoconstriction associated with various dermatoses. Clioquinol acts as a metal chelator and ionophore, disrupting microbial cell membranes and essential enzymatic processes to treat or prevent secondary bacterial and fungal infections. Developed and marketed by Offenbach in Mexico, this combination is indicated for inflammatory skin conditions, such as dermatitis and psoriasis, complicated by secondary infections.

Brand names
Cortilona compuestaCortilona compuesto
Other names
clioquinol + fluocinolone acetonideclioquinol / fluocinolone acetonideclioquinol and fluocinolone acetonidefluocinolone acetonide + clioquinolfluocinolone acetonide / clioquinolfluocinolone acetonide and clioquinol
02

Targets

GR (Glucocorticoid receptor)Zn2+/Cu2+/Fe2+/Fe3+ (Transition metal ions (Zn2+ / Cu2+ / Fe2+/Fe3+))

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