clobetasol + resveratrol

This combination therapy, developed by the University of Palermo, consists of clobetasol propionate and resveratrol delivered via a novel mucoadhesive patch for the treatment of symptomatic oral lichen planus (OLP). Clobetasol propionate is a high-potency synthetic glucocorticoid that provides robust anti-inflammatory and immunosuppressive effects by activating the glucocorticoid receptor. Resveratrol, a natural polyphenol, acts as a SIRT1 activator and modulates various inflammatory pathways, including the inhibition of NF-kappaB and COX-2, providing complementary antioxidant and immunomodulatory benefits. The mucoadhesive patch delivery system is designed to adhere to the oral mucosa and dissolve without removal, ensuring controlled and prolonged release of the active ingredients directly to the site of the lesion, which may enhance efficacy and patient compliance compared to traditional ointments or pastes.

Other names

clobetasol propionate + resveratrol mucoadhesive patchEMPATIA patchClobetasol + Resveratrol Patch