clobetasol propionate + ketoconazole

**Clobetasol propionate + ketoconazole** is a fixed-dose combination topical medication used primarily for the treatment of inflammatory skin conditions complicated by fungal infections. Clobetasol propionate is a potent synthetic corticosteroid that acts as an anti-inflammatory agent by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals and promoting anti-inflammatory gene expression, leading to reduced swelling, redness, itching, and rashes[1][5]. Ketoconazole is an imidazole antifungal agent that inhibits lanosterol 14-alpha demethylase (a cytochrome P450 enzyme), blocking ergosterol synthesis in fungal cell membranes and increasing membrane permeability, thereby preventing fungal growth[3][8]. This combination targets both inflammation (from steroid-responsive dermatoses such as eczema or psoriasis) and secondary or coexisting superficial fungal infections.

Brand names

ClobexClodanDermovateImpekloImpoyzOluxTemovateTovetNizoral A-DExtinaKetodanKuric

Other names

clobetasol topical + ketoconazole topical