Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
clomiphene citrate + dopamine agonist
- Development stage
- Preclinical
- Lead developer
- Procter & Gamble
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Clomiphene citrate + dopamine agonist is a combination therapy used to manage complex cases of hyperprolactinemia associated with secondary hypogonadism and metabolic complications, such as morbid obesity. Clomiphene citrate is a selective estrogen receptor modulator (SERM) that acts as an antagonist at estrogen receptors in the hypothalamus and pituitary gland. This action blocks the negative feedback of estrogen, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), which subsequently stimulates endogenous testosterone production in males. Dopamine agonists (such as cabergoline or bromocriptine) target D2 receptors on pituitary lactotroph cells to inhibit prolactin secretion and reduce the size of prolactin-secreting adenomas. The combination is employed when dopamine agonist monotherapy is insufficient to restore the hypothalamic-pituitary-gonadal axis or when adjunctive treatment is needed to address severe obesity and insulin resistance linked to prolactinomas.
- Other names
- clomiphene + dopamine agonist
02
Targets
ER (Estrogen receptor)DRD2 (Dopamine D2 Receptor)
Beyond the preview
Go deeper on clomiphene citrate + dopamine agonist.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on clomiphene citrate + dopamine agonist.