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clopidogrel + prasugrel + ticagrelor
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This represents a combination of three distinct P2Y12 receptor inhibitor antiplatelet drugs. Each drug has different pharmacological properties: clopidogrel and prasugrel are thienopyridines that irreversibly inhibit the P2Y12 receptor after hepatic conversion to active metabolites, while ticagrelor is a cyclopentyltriazolopyrimidine that reversibly binds to the P2Y12 receptor without requiring metabolic activation. These drugs are not typically administered simultaneously but may be used in sequence or alternation in specific clinical scenarios for patients with acute coronary syndrome.
- Brand names
- PlavixEffientEfientBrilintaPossia
- Other names
- clopidogrel + prasugrel + ticagrelor-Centre hospitalier de l'Université de Montréal (CHUM)-cardiovascular diseasesclopidogrel/prasugrel/ticagrelor
02
Targets
P2Y12 (Purinergic P2Y12 receptor)
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