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clotrimazole + betamethasone dipropionate + zinc oxide
- Development stage
- Unknown
- Lead developer
- Skya Health
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Clotrimazole + betamethasone dipropionate + zinc oxide is a **topical small-molecule combination product** consisting of clotrimazole, an imidazole antifungal that inhibits fungal ergosterol synthesis and disrupts fungal cell-membrane formation; betamethasone dipropionate, a potent corticosteroid that activates glucocorticoid receptors to suppress local inflammation, pruritus, and erythema; and zinc oxide, a skin protectant used as a barrier paste. The combination is marketed as kit products including **Clobezin** and **DermacinRx Therazole Pak** and is used for the topical treatment of symptomatic inflammatory **tinea pedis, tinea cruris, and tinea corporis** caused by susceptible dermatophytes in patients 17 years and older, while the zinc oxide component provides protective barrier support to irritated skin. The drug is a marketed pharmaceutical formulation rather than a novel molecular entity.
- Brand names
- ClobezinDermacinRx Therazole Pak
- Other names
- clotrimazole + betamethasone dipropionate + zinc oxideclotrimazole and betamethasone dipropionate cream + zinc oxide paste
02
Targets
CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)
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