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CMV-specific adoptive T-cell therapy (Mari Dallas)
- Development stage
- Unknown
- Lead developer
- Mari Dallas
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
CMV-specific adoptive T-cell therapy is an investigational cell-based immunotherapy developed for the treatment of opportunistic cytomegalovirus (CMV) infections in patients following hematopoietic stem cell transplantation (HSCT). The therapy involves selecting T-cells from a donor that are specifically reactive against CMV antigens. These selected cells are then infused into the recipient to restore or enhance the immune system's ability to control the viral infection, particularly when conventional antiviral treatments are ineffective or poorly tolerated. This specific study is led by Mari Dallas.
- Other names
- CMV specific adoptive t-cellsAntigen Specific Adoptive T Cell Therapy
02
Targets
IE1 (HCMV immediate-early protein 1)pp65/HLA-A*02:01 (CMV pp65 peptide-HLA-A*02:01 complex)
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