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Drug intelligence / Profile preview
codeine + guaifenesin
- Development stage
- Phase 1
- Lead developer
- Laboratoires Sterop
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bronchodine is a combination oral syrup containing the opioid codeine and the expectorant guaifenesin. While traditionally indicated for the symptomatic treatment of non-productive cough, it is notably used in clinical research settings, such as those at KU Leuven, as a model agent to induce opioid-induced gastroparesis. By activating mu-opioid receptors in the enteric nervous system, the codeine component significantly delays gastric emptying and alters motility patterns. This pharmacological induction of gastric dysfunction serves as a controlled baseline for evaluating novel diagnostic technologies, including intragastric balloon pressure sensors designed to monitor gastric contractility and volume changes in patients with motility disorders.
- Brand names
- Bronchodine
- Other names
- codeine/guaifenesin
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)
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