Drug intelligence / Profile preview

codeine + triprolidine (Anglo-French Drugs & Industries)

Development stage
Unknown
Lead developer
Anglo-French Drugs & Industries
Modality
Small Molecules
Administration
Oral
01

Overview

Codylex-T is an oral combination formulation containing the opioid cough suppressant codeine (as codeine phosphate) and the first-generation antihistamine triprolidine (as triprolidine hydrochloride). Developed and marketed by Anglo-French Drugs & Industries, it is primarily indicated for the symptomatic relief of dry, irritating, and allergic coughs, as well as coughs associated with the common cold or upper respiratory allergies. Codeine acts centrally on the cough center in the medulla oblongata to suppress the cough reflex, while triprolidine blocks histamine H1 receptors to alleviate allergy-mediated symptoms such as sneezing, runny nose, and watery eyes.

Brand names
Codylex TCodylex-T
Other names
codeine phosphate + triprolidine hydrochloridetriprolidine + codeinetriprolidine hydrochloride + codeine phosphate
02

Targets

DOR (Opioid Receptor Delta 1)HRH1 (Histamine H1 Receptor)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)

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