Drug intelligence / Profile preview

codeine phosphate + guaifenesin

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Codeine phosphate + guaifenesin is a combination pharmaceutical drug used primarily to relieve cough and loosen mucus in conditions such as the common cold or allergies. Codeine is an opioid that acts centrally on the medulla to suppress the cough reflex, while guaifenesin is an expectorant that thins and loosens bronchial secretions, making it easier to clear mucus from the airways. This combination provides both symptomatic relief of cough (via central suppression) and improved clearance of respiratory secretions (via increased fluidity). Codeine has potential for dependence and should be used only as prescribed for short durations[1][2][5].

Brand names
Cheratussin ACGuaiatussin ACGuaifenesin ACIophen C-NRRobitussin ACVirtussin AC
Other names
codeine/guaifenesin
02

Targets

KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)

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