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codeine phosphate + guaifenesin
- Development stage
- Phase 1
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Codeine phosphate + guaifenesin is a combination pharmaceutical drug used primarily to relieve cough and loosen mucus in conditions such as the common cold or allergies. Codeine is an opioid that acts centrally on the medulla to suppress the cough reflex, while guaifenesin is an expectorant that thins and loosens bronchial secretions, making it easier to clear mucus from the airways. This combination provides both symptomatic relief of cough (via central suppression) and improved clearance of respiratory secretions (via increased fluidity). Codeine has potential for dependence and should be used only as prescribed for short durations[1][2][5].
- Brand names
- Cheratussin ACGuaiatussin ACGuaifenesin ACIophen C-NRRobitussin ACVirtussin AC
- Other names
- codeine/guaifenesin
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)
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