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coenzyme Q10 + magnesium + riboflavin + feverfew + skullcap + piperine

Development stage: Unknown
Lead developer: Wellena
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

This combination is a multi-ingredient dietary supplement formulated for the prophylaxis of migraines and the management of chronic headaches. It integrates mitochondrial bioenergetic support agents, such as Coenzyme Q10 and Riboflavin (Vitamin B2), with Magnesium to address metabolic deficiencies and neuronal hyperexcitability associated with migraine pathophysiology. The formula includes botanical extracts: Feverfew (Tanacetum parthenium), which contains parthenolide to inhibit NF-kappaB signaling and pro-inflammatory cytokine production, and American Skullcap (Scutellaria lateriflora), traditionally used for its anxiolytic and neuroprotective effects via GABAergic modulation. Piperine is included as a bioavailability enhancer to optimize the intestinal absorption of Coenzyme Q10 and other phytochemical components.

Brand names: Migra-Well
Other names: MigraWell

Targets

ABCB1 (P-glycoprotein)ND1 (Mitochondrial electron transport chain complex I)CYP3A4 (Cytochrome P450 3A4)NMDAR (Glutamate receptor ionotropic, NMDA)

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