Drug intelligence / Profile preview

coenzyme Q10 + omega-3 fatty acids + resveratrol

Development stage
Preclinical
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

A combination supplement composed of **coenzyme Q10, omega-3 fatty acids**, and **resveratrol**, this formulation is designed to leverage the antioxidant, anti-inflammatory, and cardioprotective properties of each component. **Coenzyme Q10** is a mitochondrial cofactor essential for ATP production and acts as an antioxidant. **Omega-3 fatty acids** (primarily EPA and DHA) are long-chain polyunsaturated fatty acids known for their cardiovascular benefits, anti-inflammatory effects, and positive influence on lipid metabolism. **Resveratrol** is a polyphenol with antioxidant, anti-inflammatory, and signaling pathway modulating effects, investigated for cardiometabolic, neuroprotective, and anticancer applications. The combination has shown synergistic effects in reducing inflammation and oxidative stress, improving mitochondrial function, and stabilizing fatty acids against oxidative degradation. There is preclinical and early clinical evidence for the benefit of combined supplementation in diseases characterized by chronic inflammation and oxidative stress, including but not limited to arthritis, cardiovascular disease, and metabolic dysfunction[1][2][3].

02

Targets

NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)NADH:ubiquinone oxidoreductase subunit familyPDE (Phosphodiesterase family)

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