coenzyme Q10 + trimetazidine

Coenzyme Q10 + trimetazidine is a fixed-dose combination of two agents with complementary mechanisms used primarily for cardiovascular protection. - **Coenzyme Q10 (ubiquinone)** is a naturally occurring antioxidant involved in mitochondrial electron transport and cellular energy production. It reduces oxidative stress and supports myocardial function by improving ATP synthesis. - **Trimetazidine** is a metabolic modulator that shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation, thereby enhancing myocardial efficiency under ischemic conditions. It also exhibits antioxidant and anti-inflammatory properties. The combination has demonstrated superior efficacy over monotherapy in reducing markers of inflammation and oxidative stress, improving left ventricular systolic function, and lowering biochemical markers of myocardial damage in acute viral myocarditis[1][2][5]. It has also shown protective effects against drug-induced cardiotoxicity (e.g., cisplatin) by attenuating oxidative stress[3][6]. The primary indications studied include acute viral myocarditis, chronic heart failure, and prevention of cardiotoxicity.

Other names

coenzyme Q10 and trimetazidineCoQ10 + trimetazidineCQ10 + trimetazidineTMZ + CoQ10