Drug intelligence / Profile preview

collagen + methylsulfonylmethane + ascorbic acid

Development stage
Unknown
Lead developer
Toscana Life Sciences Foundation
Modality
Peptides, Small Molecules
Administration
Oral
01

Overview

IP2 is an investigational oral dietary supplement developed by Toscana Life Sciences, consisting of a combination of collagen peptides, methylsulfonylmethane (MSM), and ascorbic acid (vitamin C). The product is designed to enhance skin health and appearance by providing structural support, reducing inflammation, and promoting endogenous collagen synthesis. Collagen peptides serve as building blocks for the dermal extracellular matrix, while MSM acts as a sulfur donor and anti-inflammatory agent, potentially through the inhibition of NF-kappaB signaling. Ascorbic acid serves as an essential cofactor for prolyl and lysyl hydroxylase enzymes, which are critical for the post-translational modification and cross-linking of collagen fibers. Clinical evaluations have focused on parameters such as dermis density, wrinkle reduction, skin texture, and elasticity, with further studies planned to investigate its efficacy in reducing facial erythema and telangiectasia.

Other names
collagen + MSM + vitamin Ccollagen + methylsulfonylmethane + vitamin C
02

Targets

NF-κBLH (Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1)PHD1 (Prolyl hydroxylase domain-containing protein 1)

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