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compound 55 (University of Dundee)
- Development stage
- Discontinued
- Lead developer
- University of Dundee
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Compound 55 is a brain-penetrant indoline-2-carboxamide derivative developed by the University of Dundee's Drug Discovery Unit for the treatment of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Identified through phenotypic screening of a focused protease inhibitor library against *Trypanosoma brucei*, the compound is chemically characterized as a 5-fluoroindoline with a 4-fluorophenyl pendant ether moiety. It demonstrated potent antiproliferative activity against the parasite and showed high metabolic stability with favorable brain tissue distribution. While the compound achieved full cures in stage 1 (hemolymphatic) mouse models of HAT, its development was ultimately terminated due to dose-limiting tolerability issues that prevented the delivery of a fully curative regimen in stage 2 (meningoencephalitic) models.
- Other names
- 5-fluoroindoline-2-carboxamide derivative
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