copper framework + glucose oxidase

Copper framework + glucose oxidase refers to a combination of a copper-based metal-organic framework (Cu-MOF) and the enzyme glucose oxidase (GOx). This hybrid system is primarily developed as a nanomedicine platform for cancer therapy and biosensing applications. In therapeutic contexts, the Cu-MOF acts as a carrier for GOx, which catalyzes the oxidation of glucose to produce hydrogen peroxide (H₂O₂). The copper ions in the MOF can react with intracellular glutathione (GSH), depleting GSH and converting Cu²⁺ to Cu⁺. The generated H₂O₂ and reduced copper then participate in Fenton-like reactions, producing reactive oxygen species (ROS) that disrupt redox balance in cancer cells. This dual mechanism—GSH depletion and ROS elevation—can enhance chemotherapy efficacy by overcoming multidrug resistance in cancers such as MDR lung cancer[1]. In biosensing applications, similar frameworks are used for highly sensitive colorimetric or electrochemical detection of glucose due to their integrated catalytic properties[2][3].

Other names

Cu-based metal-organic framework + glucose oxidaseCu-MOF/GOx