Drug intelligence / Profile preview

corifollitropin alfa + Lyndiol

Development stage
Unknown
Lead developer
Merck
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Oral
01

Overview

Corifollitropin alfa + Lyndiol is a hypothetical or unreported combination of two drugs: corifollitropin alfa, a long-acting recombinant fusion protein that acts as a follicle-stimulating hormone (FSH) agonist used for controlled ovarian stimulation in women undergoing assisted reproductive technology procedures[1][2][3][4], and Lyndiol, a brand name for a combined oral contraceptive containing ethinylestradiol and lynestrenol, used for hormonal contraception. Corifollitropin alfa stimulates multiple follicle growth in the ovary by acting as a sustained FSH receptor agonist, replacing several daily FSH injections with a single weekly dose[1][2][3]. Lyndiol acts primarily through suppression of ovulation via inhibition of the hypothalamic-pituitary-ovarian axis, enhancing negative feedback from estrogens and progestogens. There is no known clinical use or approval for the combination of corifollitropin alfa and Lyndiol, and their mechanisms are antagonistic: corifollitropin alfa stimulates follicular growth for fertility treatment, while Lyndiol suppresses ovulation for contraception. No trials or products combine these two drugs as a single therapy. Corifollitropin alfa is developed by Merck[1], marketed as Elonva[1], and administered by subcutaneous injection[1][2][3][5]. Lyndiol is manufactured by pharmaceutical companies in Europe (not specified in provided results). No information is available describing a combination product or therapy 'corifollitropin alfa + Lyndiol' in scientific literature or regulatory documents.

02

Targets

FSHR (Follicle-stimulating hormone receptor)PR (Progesterone receptor)ER (Estrogen receptor)

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