Drug intelligence / Profile preview

corticosteroid + lidocaine

Development stage
Unknown
Lead developer
Aslinur Keles Ercisli
Modality
Small Molecules
Administration
Intraarticular
01

Overview

This combination therapy, consisting of a corticosteroid and lidocaine, is being investigated by Aslinur Keles Ercisli, MD, PhD, for the treatment of adhesive capsulitis (frozen shoulder). The formulation typically includes 1 cc of a corticosteroid, 4 cc of 2% lidocaine, and 5 cc of saline, administered via intra-articular injection. The corticosteroid component functions as a glucocorticoid receptor agonist, exerting potent anti-inflammatory effects to reduce joint capsule fibrosis and pain. Lidocaine acts as a local anesthetic by blocking voltage-gated sodium channels, providing immediate symptomatic relief. The clinical research focuses on comparing different injection techniques—anterior, posterior, and combined—to optimize therapeutic outcomes in patients with stage 2 adhesive capsulitis.

Other names
corticosteroid + lidocaine + saline
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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