coumarin + troxerutin

Coumarin + troxerutin is an oral fixed-dose venoactive combination used for symptomatic treatment of **chronic venous insufficiency** and associated venous or lymphatic edema. Coumarin is a benzopyrone with lymphokinetic and anti-edematous activity, while troxerutin is a hydroxyethylated flavonoid derivative with capillary-protective, antioxidant, and vascular permeability-modulating effects. The combination has been marketed under brands including Venalot and evaluated in placebo-controlled studies, including Takeda's completed Phase 4 VENACT study in chronic venous insufficiency. ([clinicaltrials.takeda.com](https://clinicaltrials.takeda.com/study-detail/5f6b603a4db2bf003ab4a25c))

Brand names

AngiolotEsberivenFlebotratVenalotVenalot DepotVenalot SR

Other names

coumarin/troxerutintroxerutin + coumarin