Drug intelligence / Profile preview

COVID-19 convalescent plasma (William Beaumont Hospitals)

Development stage
Unknown
Lead developer
Corewell Health
Administration
Intravenous
01

Overview

COVID-19 convalescent plasma (William Beaumont Hospitals) is a biological therapy consisting of plasma collected from individuals who have recovered from COVID-19. This plasma contains neutralizing antibodies, specifically IgG and IgA, against the SARS-CoV-2 virus. The therapy aims to provide passive immunity to hospitalized patients with COVID-19, potentially reducing viral load and improving clinical outcomes. The specific program at William Beaumont Hospitals (now Corewell Health) involved the ABACCuS trial, which evaluated the safety and efficacy of the plasma based on the antibody levels present in the donor units. The study specifically analyzed outcomes in patients requiring supplemental oxygen or mechanical ventilation, correlating recovery with the concentration of anti-SARS-CoV-2 antibodies in the administered plasma.

Other names
COVID-19 convalescent plasmaCOVID19 convalescent plasmaCOVID 19 convalescent plasmaConvalescent Plasma
02

Targets

RBD (SARS-CoV-2 spike receptor-binding domain)

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