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COVID-19 convalescent plasma (William Beaumont Hospitals) is a biological therapy consisting of plasma collected from individuals who have recovered from COVID-19. This plasma contains neutralizing antibodies, specifically IgG and IgA, against the SARS-CoV-2 virus. The therapy aims to provide passive immunity to hospitalized patients with COVID-19, potentially reducing viral load and improving clinical outcomes. The specific program at William Beaumont Hospitals (now Corewell Health) involved the ABACCuS trial, which evaluated the safety and efficacy of the plasma based on the antibody levels present in the donor units. The study specifically analyzed outcomes in patients requiring supplemental oxygen or mechanical ventilation, correlating recovery with the concentration of anti-SARS-CoV-2 antibodies in the administered plasma.
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