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COVID-19 convalescent plasma-Brigham and Women's Hospital-COVID-19
- Development stage
- Unknown
- Lead developer
- Mass General Brigham
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
COVID-19 convalescent plasma developed by Brigham and Women's Hospital, in collaboration with Massachusetts General Hospital, is a passive polyclonal antibody biologic therapy. It consists of plasma collected from donors who have recovered from COVID-19, containing high titers of SARS-CoV-2-specific neutralizing antibodies targeting the viral spike and nucleocapsid proteins. The therapy was evaluated in the Phase 3 ESCAPE (Evaluation of the SARS-CoV-2 Antibody-containing Plasma thErapy) trial to determine its efficacy in improving clinical outcomes for hospitalized patients with moderate COVID-19 by neutralizing the virus and modulating the immune response.
- Other names
- High-Titer COVID-19 Convalescent PlasmaESCAPE trial convalescent plasma
02
Targets
SARS-CoV-2 spikeN (Nucleocapsid protein)
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