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CPX-351 (daunorubicin + cytarabine) (Jazz Pharmaceuticals plc, 043505)
- Development stage
- Phase 4
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
CPX-351 (Vyxeos) is a liposomal encapsulation of cytarabine and daunorubicin in a fixed 5:1 molar ratio. It is designed to optimize the synergistic delivery of these two agents to leukemia cells while minimizing systemic toxicity. Cytarabine is a pyrimidine analog that inhibits DNA polymerase, while daunorubicin is an anthracycline that intercalates into DNA and inhibits topoisomerase II. CPX-351 was developed by Celator Pharmaceuticals (now Jazz Pharmaceuticals) and is primarily indicated for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC).
- Brand names
- Vyxeos
- Other names
- daunorubicin and cytarabine liposomeliposomal cytarabine and daunorubicindaunorubicin-cytarabine liposome
02
Targets
POLE (DNA polymerase epsilon)DNATOP2A (DNA topoisomerase II)
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