CR BNO 1055 + tamoxifen

CR BNO 1055 + tamoxifen is a combination of a standardized extract of Cimicifuga racemosa (black cohosh), known as CR BNO 1055, and the selective estrogen receptor modulator (SERM) tamoxifen. - **CR BNO 1055** is an ethanolic extract of black cohosh rhizome used primarily for menopausal symptoms such as hot flashes and night sweats. Its mechanism appears to involve modulation of serotonin receptors (notably 5-HT1A and 5-HT7), dopaminergic activity via D2 receptors, possible μ-opioid receptor affinity, and SERM-like effects in certain tissues without uterotrophic activity[1][6][7]. - **Tamoxifen** is a well-established SERM that acts as an estrogen receptor antagonist in breast tissue but can have agonist effects in other tissues. It is widely used for hormone receptor-positive breast cancer treatment and prevention. The rationale for combining these agents may be to manage menopausal symptoms or mitigate side effects associated with endocrine therapy in women with or at risk for breast cancer.

Brand names

KlimadynonMenofemRemifeminNolvadex

Other names

Cimicifuga racemosa extract + tamoxifenblack cohosh extract + tamoxifen