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crizotinib + Endostar
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination therapy consisting of crizotinib and Endostar (recombinant human endostatin). Crizotinib is a tyrosine kinase inhibitor that targets ALK, ROS1, and c-Met, used primarily for treating ALK-positive or ROS1-positive non-small cell lung cancer. Endostar is a recombinant human endostatin that has anti-angiogenic properties. The combination may be investigated for potential synergistic effects in cancer treatment.
02
Targets
MET (Mesenchymal-epithelial transition factor receptor)ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)
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