crocin + selenium

Crocin + selenium is a **combination therapy** typically formulated as **nanoparticles** or physical mixtures intended for synergistic antioxidant and therapeutic effects. Crocin is a carotenoid compound found in saffron (*Crocus sativus*), known for its antioxidant, anti-inflammatory, neuroprotective, and anticancer properties, achieved by inhibiting monoamine oxidase (MAO) enzyme activity, blocking serotonin reuptake, modulating nuclear factor-kappa B pathway activity, and reducing pro-inflammatory cytokines[4]. Selenium, an essential trace element, functions pharmacologically as an antioxidant and immunomodulator by being incorporated into selenoproteins (including glutathione peroxidase and thioredoxin reductase), influencing oxidative stress, immune response, and cellular survival[5][6]. When combined, especially as crocin-conjugated selenium nanoparticles, the formulation shows enhanced efficacy in preclinical models for cancer via increased cytotoxicity and apoptosis induction, and in human studies has demonstrated improvement in cognitive impairment and antioxidant markers in multiple sclerosis patients[1][3]. Nanoparticle delivery (e.g., PEG-functionalized SeNPs) allows for targeted release, increased bioavailability, and reduction in side effects, establishing this combination as a promising approach for indications associated with oxidative stress or inflammation.

Other names

crocin-selenium nanoparticlesCor@SeNs