Drug intelligence / Profile preview

curcuma + phospholipids

Development stage
Unknown
Lead developer
Indena
Modality
Small Molecules, Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

Curcuma + phospholipids refers to a class of dietary supplement formulations in which **curcumin** (the principal active component of the spice turmeric, *Curcuma longa*) is complexed or combined with **phospholipids** (such as phosphatidylcholine or soy lecithin) to significantly enhance curcumin's bioavailability and cellular uptake. Curcumin acts as an anti-inflammatory and antioxidant agent by modulating multiple cell signaling pathways, including nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2), and various cytokines. The phospholipids act as absorption enhancers, allowing for better penetration of curcumin through cell membranes and increased systemic presence. Such formulations are primarily marketed for support of joints, bones, gastrointestinal health, and immune system function[1][2][3][4][7].

Brand names
MerivaCurcumin K2Curcuma Phospholipids
Other names
curcumin + phospholipidsphospholipidated curcuminphospholipid curcumin formulationcurcumin phospholipid complex
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HDAC8 (Histone Deacetylase 8)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))NFKB1 (NF-κB1)

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