Drug intelligence / Profile preview

curcuma longa extract + boswellia serrata extract

Development stage
Unknown
Lead developer
Akay Bioactives
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination of botanical extracts derived from **Curcuma longa** (turmeric; containing curcumin as the principal active constituent) and **Boswellia serrata** (Indian frankincense; containing boswellic acids, notably 3-O-acetyl-11-keto-β-boswellic acid [AKBA]). Both extracts are widely used in traditional and modern medicine, primarily for their **anti-inflammatory** and **analgesic** effects. The combination is researched mostly as an oral dietary supplement for the management of pain and inflammation in **osteoarthritis**, musculoskeletal conditions, spondylitis, and as an adjunct in other inflammatory disorders. Proposed mechanisms of action include: inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) pathways, suppression of pro-inflammatory cytokines (e.g., IL-1, TNF-α, IL-6), antioxidant effects via activation of Nrf2-related pathways, and inhibition of leukotriene and prostaglandin synthesis. Clinical studies suggest the combination may have additive or synergistic benefits versus monotherapy, resulting in symptom relief and functional improvement in osteoarthritis and other inflammatory states[1][2][3][4].

Brand names
Curamin
Other names
turmeric extract + boswellia extractcurcumin + boswellic acidsCB formulation
02

Targets

ALOX5 (Arachidonate 5-lipoxygenase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)TNFA (Tumor necrosis factor alpha (soluble))ALOX12 (Arachidonate 12-lipoxygenase, 12S type)IL1A (Interleukin 1 alpha)NF-κB

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