Drug intelligence / Profile preview

curcumin + boswellia + ascorbic acid

Development stage
Preclinical
Lead developer
Akay Bioactives
Modality
Small Molecules
Administration
Oral
01

Overview

A combination dietary supplement containing **curcumin** (the primary active constituent of turmeric), **boswellia** (extracts from Boswellia serrata, often standardized for boswellic acids), and **ascorbic acid** (vitamin C)[2][4][6]. Curcumin exhibits anti-inflammatory and antioxidant properties by modulating pathways such as Nrf2 and inhibiting pro-inflammatory cytokines and enzymes like cyclooxygenase and lipoxygenase[3]. Boswellia is known for anti-inflammatory effects primarily through inhibition of 5-lipoxygenase and modulation of inflammatory signaling (including TLR pathways and cytokines), acting via the PPARα and Nrf1 pathways; both agents show potential in management of joint and musculoskeletal inflammation[1][3]. Ascorbic acid (vitamin C) acts as an antioxidant and immune modulator, supporting connective tissue health and collagen synthesis, and is included to enhance overall anti-inflammatory and antioxidant effects[2][4]. The combination is designed to provide **synergistic reduction in inflammation, pain, and oxidative stress**, with particular application for **joint disorders (osteoarthritis, spondylitis)**, immune function, and general wellness[1][3][5]. These supplements are not pharmaceuticals, but rather nutraceutical formulations manufactured by various dietary supplement companies, sometimes with advanced delivery technologies to increase bioavailability[1][2][4].

02

Targets

NFE2L1 (Nuclear respiratory factor 1)TLR (Toll-like receptors)NF-κBMMP12 (Macrophage Metalloelastase)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)COXKEAP1 (Kelch-like ECH-associated protein 1)PPARA (Peroxisome proliferator-activated receptor alpha)

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