Drug intelligence / Profile preview

cyanocobalamin + salcaprozate sodium

Development stage
Unknown
Lead developer
Novo Nordisk
Modality
Small Molecules
Administration
Oral
01

Overview

Cyanocobalamin + salcaprozate sodium is an oral combination formulated to improve vitamin B12 (cyanocobalamin) absorption using the absorption enhancer salcaprozate sodium (also known as SNAC). Salcaprozate sodium facilitates the transport of vitamin B12 across the gastric lining, significantly enhancing its bioavailability relative to standard oral cyanocobalamin. This formulation was designed particularly for the treatment of vitamin B12 deficiency, especially in patients with malabsorption syndromes. It is classified as a "medical food" rather than a conventional pharmaceutical drug, providing pharmacokinetic and efficacy profiles that approach those of injectable B12, with similar safety. The combination formulation was developed by Emisphere Technologies and marketed under the brand name Eligen B12[1][3].

Brand names
Eligen B12
Other names
cyanocobalamin + SNACcyanocobalamin + sodium N-[8-(2-hydroxybenzoyl)amino]caprylatecyanocobalamin + salcaprozate sodium
02

Targets

MTR (Methionine synthase)Vitamin B12 transporter

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