cyclizine + dexamethasone

Cyclizine + dexamethasone is a combination of two pharmaceutical drugs used primarily for the prevention and management of nausea and vomiting, particularly in postoperative settings and palliative care. Cyclizine is a piperazine-derivative antihistamine with antiemetic, antivertigo, anticholinergic, and central nervous system depressant properties. It acts mainly by blocking histamine H1 receptors and exerting anticholinergic effects on the medullary chemoreceptor trigger zone to reduce nausea and vomiting[10][7]. Dexamethasone is a synthetic fluorinated glucocorticoid with potent anti-inflammatory and immunosuppressive actions; it reduces inflammation by binding to glucocorticoid receptors, modulating gene expression, suppressing pro-inflammatory cytokines, and stabilizing cell membranes[6][8]. The combination may be used when single-agent therapy is insufficient or as part of multimodal antiemetic regimens in perioperative or cancer care settings[1][7].