cyclo(histidyl-proline) + zinc

Cyclo(histidyl-proline) + zinc is a combination of **cyclo(His-Pro)** (CHP), a cyclic dipeptide found in the central nervous system, and **zinc**. CHP is derived from the hydrolytic removal of the pyroglutamic acid residue of hypothalamic thyrotropin-releasing hormone (TRH), and functions as a neuroprotective agent by modulating organic cation transporters, crossing the blood-brain barrier, and altering inflammatory and stress responses via pathways like Nrf2-NF-κB. Zinc acts as a critical trace element influencing insulin sensitivity, glucose metabolism, and neuroprotection. The combination has been investigated for its roles in increasing muscle zinc uptake, ameliorating insulin resistance in diabetic animal models, enhancing insulin-degrading enzyme (IDE) synthesis, and potentially preventing or treating conditions like diabetes and obesity. CHP plus zinc also increases antioxidant capacity and exhibits anti-apoptotic and anti-necrotic properties in cellular models of neurodegeneration, including Alzheimer's disease. Clinical studies have shown oral Cyclo-Z to be well tolerated and without significant acute toxicity in healthy adults[1][2][4].

Brand names

Cyclo-Z

Other names

CHP + zinccyclo(His-Pro) plus zincCyclo(His-Pro) + zinc