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Drug intelligence / Profile preview
cyclopentolate + phenylephrine
- Development stage
- Approved
- Lead developer
- Alcon
- Modality
- Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Ophthalmic
01
Overview
Cyclopentolate + phenylephrine is a fixed-dose combination ophthalmic solution used to induce mydriasis (pupil dilation) for diagnostic eye examinations. Cyclopentolate is an anticholinergic agent that relaxes the sphincter muscle of the iris, leading to pupil dilation and some paralysis of accommodation (cycloplegia). Phenylephrine is an adrenergic agonist that stimulates alpha-1 adrenergic receptors in the dilator muscle of the iris, causing further pupil dilation through vasoconstriction. The combination provides greater mydriatic effect than either drug alone at their respective concentrations, with minimal cycloplegia. It is commonly used prior to eye exams or procedures requiring a dilated pupil[1][2][4][5].
- Brand names
- Cyclomydril
- Other names
- cyclopentolate and phenylephrine ophthalmiccyclopentolate hydrochloride and phenylephrine hydrochloride ophthalmic solution
02
Targets
ADRA1A (α1A)CHRM3 (M3)CHRM4 (M4)
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