Cyclophosphamide, Methotrexate, and Aspirin Combination

This is a combination therapy consisting of three distinct medications: 1. **Cyclophosphamide**: An alkylating agent that belongs to the nitrogen mustard family. It works by interfering with DNA replication and RNA transcription, preventing cell division. 2. **Methotrexate**: An antimetabolite and antifolate drug that inhibits dihydrofolate reductase, an enzyme involved in the metabolism of folic acid. This disrupts DNA synthesis and cell division. 3. **Aspirin**: A non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes and has anti-inflammatory, analgesic, and antiplatelet properties. The combination has been studied in various contexts, particularly in cancer treatment regimens. Low-dose cyclophosphamide and methotrexate have been used in metronomic chemotherapy approaches targeting angiogenesis in advanced cancers[1]. However, the search results indicate that aspirin may increase blood levels and side effects of methotrexate, creating a potentially significant drug interaction that requires careful monitoring[5][6].

Other names

Metronomic CM and AspirinLow-dose metronomic cyclophosphamide and methotrexate with aspirin