cyclophosphamide + corticosteroids + azathioprine

**Cyclophosphamide + corticosteroids + azathioprine** is a combination of three immunosuppressive agents frequently employed to treat severe or refractory autoimmune disorders. - **Cyclophosphamide** is an alkylating agent that suppresses immune activity by cross-linking DNA, inhibiting DNA replication and lymphocyte proliferation. - **Corticosteroids** are synthetic hormones that bind glucocorticoid receptors, exerting broad anti-inflammatory and immunosuppressive effects via transcriptional regulation of inflammatory mediators. - **Azathioprine** is a purine antimetabolite blocking lymphocyte proliferation by inhibiting nucleic acid synthesis. This combination is sometimes used as induction or escalation therapy for immune-mediated diseases such as lupus nephritis, pemphigus vulgaris, Crohn's disease, and certain interstitial lung diseases, typically in patients not responding to single-agent therapy. Combination therapy is intended to rapidly induce disease remission by targeting multiple immune pathways. Risks include cumulative immunosuppression and increased infectious and toxicity burden[1][2][3][4][6].

Other names

cyclophosphamide + corticosteroids + azathioprine