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cyclophosphamide + docetaxel + pertuzumab + trastuzumab
- Development stage
- Phase 2
- Lead developer
- Roche
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral, Subcutaneous
01
Overview
This combination is used for the treatment of HER2-positive breast cancer. **Cyclophosphamide** is a chemotherapy drug that works by interfering with DNA replication. **Docetaxel** is another chemotherapy agent that disrupts microtubule function, preventing cell division. **Pertuzumab** and **trastuzumab** are monoclonal antibodies targeting the HER2 protein, which is overexpressed in some breast cancers. They work by binding to different parts of the HER2 protein, preventing its dimerization and signaling, thus inhibiting cancer cell growth.
02
Targets
DNAMicrotubuleERBB2 (Erb-b2 receptor tyrosine kinase 2)
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